With 2.4 billion people suffering from food insecurity globally, this research offers an innovative solution to conventional farming methods through aquaponics. Aquaponics combines aquaculture (raising fish) with hydroponics (soilless plant cultivation) in a closed-loop system, eliminating the need for synthetic fertilizers while simultaneously facilitating resource maximization. This study assessed the economic viability of aquaponics as a model for sustainable agriculture using Python-based analysis of 1,140 vegetable combinations at the NGO Casita Copán in Honduras. By integrating economic modeling with sustainable agriculture, the study highlights aquaponics as a transformative tool for resilient food systems, supporting the SDGs through resource-efficient, community-driven practices.